As a means of increasing the benefits derived from experimental animals while minimizing the number of animals used, the ARC encourages the sharing of animal tissues between investigators[1]. Although formal ARC approval is not required for the use of animal tissues, the Committee requires the following:

  1. Investigators sharing tissues from animals infected with biohazardous agents or treated with carcinogens, radioisotopes, or covered DNA[2] must meet the requirements of, and obtain appropriate approvals from, the Campus Veterinarian, Biosafety Officer, and Radiation Safety Officer before any transfer occurs.
  2. If tissues or extracts, or products of tissues, are to be reintroduced into live animals, advance approval will be obtained from the Campus Veterinarian so that appropriate measures may be instituted to avoid the spread of pathogens.
  3. If modifications to the ARC protocol are required to accommodate the use or transfer of tissues, ARC review and approval of an amendment application is required prior to implementation of such changes.
  4. Submission of a Tissue Sharing Form to the ARC, with the exception of the following cases:
    • Transfer between UCLA investigators, provided a) both investigators have approved ARC protocols, b) the tissue being obtained originates from the same genus as that listed in the recipient investigator's protocol, and c) the tissue originates from laboratory rats, laboratory mice, birds, or cold-blooded vertebrates. Please note that although completion of a Tissue Sharing Form is not required in these cases, investigators are still expected to meet requirements #1-3 (see above).
    • Transfer from a UCLA investigator to an outside institution, provided the tissue originates from laboratory rats, laboratory mice, birds, or cold-blooded vertebrates.
  5. All other tissue transfers, both within UCLA as well as between UCLA and outside institutions, require completion of the Tissue Sharing Form.

[1] Tissues obtained from animals slaughtered for commercial food production do not require submission of a Tissue Sharing Form.
[2] Generally, covered DNAs are DNAs for infectious viruses, DNAs for defective viruses in the presence of helper virus, or DNAs that encode toxic proteins. Covered DNAs are described in more detail in the NIH Guidelines for Research Involving Recombinant and Synthetic Nucleic Acid Molecules, Section III. If you have any doubts, please contact the IBC Administrative Office at 310-794-0262.

Approved 1/28/02; Revised 3/22/04, 8/11/08; Updated 7/12/17