Non-Rodents

All genetically modified non-rodent animals (both vertebrate and invertebrate) are subject to the NIH Guidelines and require IBC registration. This includes genetically-modified fish, flies, worms, etc.

Rodents

Certain genetically-modified rodents are exempt from IBC registration. In general, if your response is NO to the following questions, your rodent strain is exempt from IBC registration:

For Parental Rodent Strains:

  1. Was this strain(s) created at UCLA or contracted out by UCLA?
  2. Was this strain(s) created using a viral vector?
  3. Does the genetic modification confer expression of any microbial pathogen genomic region?
  4. Is the genetic modification hazardous in any way as to potentially require BSL-2 containment or higher (e.g., Does the genetic modification confer expression of a toxin)?

If crossing two different genetically modified rodent strains:

  1. Do the parental lines or the resultant offspring require BL2 or higher containment?
  2. Were these animals created with non-replicative viral vectors such that more than one-half of the viral genome from a single family of viruses will be present in the parental strain or in the subsequent crosses of these strains?
  3. Were any of the parental transgenes under the control of a gammaretroviral LTR [e.g., MLV, MoSCV)]?

If you have determined your rodent strain is exempt based on the questions above, please email ibc@research.ucla.edu so that we can record this exemption. If in doubt, please email ibc@research.ucla.edu to determine whether IBC registration is needed.