All genetically modified non-rodent animals (both vertebrate and invertebrate) are subject to the NIH Guidelines and require IBC registration. This includes genetically-modified fish, flies, worms, etc.


Certain genetically-modified rodents are exempt from IBC registration. In general, if your response is NO to the following questions, your rodent strain is exempt from IBC registration:

For Parental Rodent Strains:

  1. Was this strain(s) created at UCLA or contracted out by UCLA?
  2. Was this strain(s) created using a viral vector?
  3. Does the genetic modification confer expression of any microbial pathogen genomic region?
  4. Is the genetic modification hazardous in any way as to potentially require BSL-2 containment or higher (e.g., Does the genetic modification confer expression of a toxin)?

If crossing two different genetically modified rodent strains:

  1. Do the parental lines or the resultant offspring require BL2 or higher containment?
  2. Were these animals created with non-replicative viral vectors such that more than one-half of the viral genome from a single family of viruses will be present in the parental strain or in the subsequent crosses of these strains?
  3. Were any of the parental transgenes under the control of a gammaretroviral LTR [e.g., MLV, MoSCV)]?

If you have determined your rodent strain is exempt based on the questions above, please email so that we can record this exemption. If in doubt, please email to determine whether IBC registration is needed.