If your animal research involves the use of hazardous agents (e.g., radioisotopes, infectious agents, recombinant DNA, etc.), you must obtain approval of the Radiation Safety Officer or the Biosafety Officer before approval of your application can be issued. Since the use of animals in experimentation involving hazardous agents requires special considerations, the application describing the procedures and the facilities to be used may require review by both the Radiation Safety Committee and the Biosafety Committee, as well as the ARC. Principal investigators should assess the potential hazards of such agents and implement adequate safeguards to ensure the safe conduct of the research and to protect the health and safety of research personnel and the environment at large.