ARC Policies
- General
- Audio and Video Recording of Institutionally Owned Animals (approved 2/2023)
- Authority of the Attending Veterinarian (reviewed 8/2022)
- Investigating Allegations of Mistreatment or Other Noncompliance Issues (revised 8/2022)
- Monitoring Laboratory Animals (revised 2/2023)
- Notification of Investigators with Sick or Injured Animals (revised 6/2023)
- Reporting Adverse Events (approved 2/2023)
- Reporting Allegations of Mistreatment or Other Noncompliance Issues (revised 8/2022)
- Review of Significant Changes to Previously Approved Protocols (revised 4/2017, updated 2/2022)
- Treatment and Use of Animals Under Expired Protocols (revised 2/2023)
- Procedures
- Blood Collection from Laboratory Animals (revised 2/2013, updated 12/2015)
- Use of Fluids and Diluted Drugs in Research Animals (approved 3/2023)
- Tissue Collection for DNA Extraction for Genotyping in Rodents (revised 11/2013)
- Toe-Clipping for Animal Identification (revised 4/2023)
- Special Consideration
- Care of Experimental Allergic Encephalomyelitis (EAE) Mice (revised 2/2008)
- Maintenance of Chronic Implants (revised 8/2009)
- Monoclonal Antibody Production (revised 4/2010)
- Neuromuscular Blocking Agents (revised 4/2010)
- Pain Categorization for Animals Involved in Experiments Using Electrical Shock Stimulation (revised 1/2010)
- Physical Restraint of Unanesthetized Animals (revised 4/2010)
- Polyclonal Antibody Production (revised 7/2009)
- Restricted Access to Food (revised 7/2010, updated 7/2019)
- Restricted Access to Water (revised 5/2020, updated 7/2019)
- Status Epilepticus in Rodents (revised 12/2009)
- Tumor Development in Rodents (revised 1/2015)
- Euthanasia
- Death as an Endpoint (retired 7/2019)
- Euthanasia of Adult Rodents by Physical Methods (revised 11/2016)
- Euthanasia of Fetuses and Neonates - Mice and Rats (revised 9/2011)
- Humane Treatment and Endpoints (approved 7/2019)
- PHS Policy Clarification Regarding Use of Carbon Dioxide for Euthanasia of Small Laboratory Animals, NIH Notice, issued July 17, 2002
- Rodent CO2 Euthanasia (revised 7/2023)
- Use of Ether for Anesthesia or Euthanasia (reviewed 2/2023)
- Surgery
- Expired Medical Materials (revised 3/2023)
- Multiple Survival Surgeries (revised 6/2003)
- Non-survival Surgical Procedures (revised 4/2015, updated 7/2019)
- Oocyte Collection in Frogs (retired 2/2023)
- Post-operative Analgesia (revised 6/2010)
- Procedures Performed on USDA-Covered Species Involving the Use of General Anesthesia (revised 12/2022, updated 1/2011)
- Survival Surgery in Mice, Rats, and Birds (revised 8/2014)
- Survival Surgery in USDA-Covered Species (revised 12/2013)
- Use of Investigator-Maintained Survival Surgical Facilities for Non-USDA-Covered Species (revised 8/2023)
- Use of Pharmaceutical-Grade Compounds (revised 9/2023)
- Animal Care, Management, and Housing
- Acclimation and Quarantine (revised 1/2020)
- Breeding Colony Management (revised 6/2018)
- Environmental Enrichment (revised 9/2018)
- Maintaining Animals in Study Areas (revised 4/2017, updated 2/2020)
- Social Housing (revised 9/2018, updated 11/2022)
- Tracking and Reporting Animal Numbers (revised 1/2020)
- Animal Transport
- Animal Export (revised 1/2023)
- Animal Use in Human Clinical Facilities (revised 1/2023)
- Transporting Animals in Public Access Areas and Off Campus (revised 8/2021)
- Other
- Assigning Correction Deadlines (revised 1/2023)
- Estimating the Number of Animals (revised 1/2004)
- Tissue Sharing Requirements (retired 11/2021)
- Use of Fertilized Non-Mammalian Embryos (revised 2/2023)
Administrative Oversight of Animal Care and Use
Instructions for Animal Use Protocols
- When to Submit an Application to Use Animal Subjects
- Basic Instructions for Completing the Application
- Meeting Schedule and Submission Deadlines
- Pre-Committee Review
- Approval Notification
- Modification to an Approved Protocol
- Experimental Design & Justification for Requested Number of Animals
- Personnel Qualifications and Certification Program
- Research Involving Hazardous Agents
- Breeding Colonies
- Tissue Sharing
- Training Grants
Animal Acquisition and Housing
Occupational Health and Safety
- Medical History Questionnaire
- Toxic and Hazardous Chemicals
- Safety Procedures in the Use of Laboratory Animals
Veterinary Care
- Division of Laboratory and Animal Medicine
- Preventive Medicine
- Surveillance, Diagnosis, Treatment and Control of Disease
- Surgery and Postsurgical Care
- Euthanasia
Selecting a Model for Research
Alternatives to the Use of Animals in Research
- Alternatives to the Use of Animals in Research
- Modification of Existing Animal Use
- Use of Animal Derived Material
- Chemical, Physical and Mechanical Models
- Mathematical and Computer Models
- Legislative Mandate for the Development of Alternatives to Animal Use
Ethical and Humane Considerations in the Use of Animals for Research and Teaching
- Ethical Positions on Animal Use
- Subjective Experience in Animals
- Captivity and Suffering
- Recognizing Signs of Distress in Laboratory Animals
Page Last Updated: September 18, 2023