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The ARC Policy on Review of Significant Changes to Previously Approved Protocols has recently been revised; the updated Policy is available at This policy is intended to clarify the process for determining what constitutes a “significant change” to an approved ARC protocol, and to describe the process for review of these activities, taking into consideration the 2014 OLAW guidance on Significant Changes to Animal Activities.

Please contact the Office of Animal Research Oversight at 310-206-6308 or if you have any questions.