Posted On

The ARC Policy on Review of Significant Changes to Previously Approved Protocols has been revised to define the acceptable limit for increases in animal numbers that may be reviewed outside of the designated member and full committee review processes. The updated Policy is available at

This policy describes the process for determining what constitutes a “significant change” to an approved ARC protocol, as well as how such changes are reviewed, and is based on the 2014 OLAW guidance on Significant Changes to Animal Activities.

Please contact the Office of Animal Research Oversight at 310-206-6308 or if you have any questions.